Doxy-PEP for
STI Prevention
Post-exposure prophylaxis with doxycycline to reduce bacterial STI risk by up to 90% in eligible populations, per clinical trial data. Prescribed by licensed Florida providers — $6.60/mo.
Florida residents & visitors only
STI Risk Reduction (DoxyPEP Trial)
/30ct Doxycycline
Provider Response
Video Call Required
What is doxy-PEP?
Doxy-PEP (doxycycline post-exposure prophylaxis) is a preventive strategy where a single dose of doxycycline is taken within 72 hours after condomless sex to reduce the risk of bacterial sexually transmitted infections. Clinical trials have shown it can reduce the incidence of syphilis, chlamydia, and gonorrhea by up to 90% in certain populations.
The CDC issued guidelines in 2024 supporting doxy-PEP for men who have sex with men (MSM) and transgender women who have had a bacterial STI in the past 12 months. It represents a major advancement in STI prevention alongside condoms and PrEP for HIV.
Key points about doxy-PEP
- Take 200mg doxycycline within 72 hours of condomless sex
- Shown to reduce syphilis, chlamydia, and gonorrhea risk
- Recommended by CDC for eligible populations
- Does not replace condoms or HIV PrEP
- Requires provider evaluation and ongoing monitoring
If you are at risk for bacterial STIs, doxy-PEP may be an important addition to your prevention strategy. Talk to a provider to see if you are eligible.
Preventive care made accessible
Complete a health questionnaire about your sexual health history and STI risk — takes about 5 minutes
A licensed Florida provider reviews your eligibility within 24–48 hours
Doxycycline prescription sent to your pharmacy
Follow up for STI screening and ongoing monitoring — your provider is available anytime
Affordable STI prevention
We prescribe generic doxycycline at a fraction of brand-name prices via Cost Plus Drugs.
| Medication | Used For | Cost Plus Price |
|---|---|---|
| Doxycycline 100mg (30ct — take 2 tabs = 200mg per exposure) | Post-exposure prophylaxis | $6.60/30ct |
Members save more
With a $69/mo membership, your message visit is included — so you only pay for the medication. Become a member →
Your prescription, your pharmacy. We send prescriptions to any pharmacy you choose — CVS, Walgreens, your local pharmacy, or home delivery through Cost Plus Drugs. The prices above reflect Cost Plus Drugs pricing.
Frequently asked questions
Common questions about doxy-PEP treatment at Goza Health.
What is doxy-PEP and how does it work?
Doxy-PEP (doxycycline post-exposure prophylaxis) is a single 200mg dose of doxycycline taken within 72 hours of condomless sex. Studies show it reduces the risk of chlamydia, syphilis, and gonorrhea by up to 90%.
Who should consider doxy-PEP?
The CDC recommends doxy-PEP for men who have sex with men (MSM) and transgender women who have had a bacterial STI in the past 12 months or are on HIV PrEP.
Do I need a video call?
No. Complete a message visit describing your situation, and a licensed provider reviews your case within 24-48 hours.
How much does a doxy-PEP visit cost?
A single message visit costs $79. Members ($69/mo) get message visits included. Doxycycline through Cost Plus Drugs starts at just $6.60.
Does doxy-PEP replace PrEP for HIV?
No. Doxy-PEP prevents bacterial STIs only. It does not protect against HIV. Continue your HIV PrEP regimen as prescribed.
Is doxy-PEP safe to use regularly?
Current evidence supports ongoing use for those at continued risk. Your provider will discuss your individual situation.
Can I get a standing prescription?
Yes. Your provider can prescribe a supply of doxycycline to keep on hand, so you have it available when needed.
How effective is doxy-PEP at preventing STIs?
Clinical trials show doxy-PEP reduces the risk of chlamydia by approximately 88%, syphilis by 87%, and gonorrhea by about 55%. It’s one of the most significant advances in STI prevention in recent years.
When exactly should I take doxy-PEP?
Take 200mg (two 100mg tablets) as soon as possible after a potential exposure — ideally within 24 hours, and no later than 72 hours. Earlier is better for maximum effectiveness.
Can I take doxy-PEP and PrEP at the same time?
Absolutely. Doxy-PEP prevents bacterial STIs while PrEP prevents HIV — they work through completely different mechanisms and complement each other well.
Will doxy-PEP cause antibiotic resistance?
Current research has not shown clinically significant resistance with doxy-PEP use. Your provider stays up to date on the latest guidelines and will discuss any new developments.